Type: Package
Package: refineR
Version: 2.0.0
Date: 2025-11-05
Encoding: UTF-8
Title: Reference Interval Estimation using Real-World Data
Author: Matthias Beck [aut, cre] (ORCID:
    <https://orcid.org/0009-0008-7678-4581>),
  Tatjana Ammer [aut] (ORCID: <https://orcid.org/0000-0003-2809-0266>),
  Christopher M Rank [aut],
  Andre Schuetzenmeister [aut] (ORCID:
    <https://orcid.org/0000-0002-2964-5502>)
Maintainer: Matthias Beck <matthias.beck.mb1@roche.com>
Authors@R: c(
    person(given ="Matthias", family = "Beck", email ="matthias.beck.mb1@roche.com", role =c("aut", "cre"), comment = c(ORCID = "0009-0008-7678-4581")),
	person(given ="Tatjana", family ="Ammer", email ="tatjana.ammer@roche.com", role ="aut", comment = c(ORCID = "0000-0003-2809-0266")),
	person(given ="Christopher M", family = "Rank", email ="christopher.rank@roche.com", role ="aut", comment = c(ORCID = "")),
	person(given ="Andre", family ="Schuetzenmeister", email ="andre.schuetzenmeister@roche.com", role ="aut", comment = c(ORCID = "0000-0002-2964-5502")))
Depends: R (>= 3.2.0)
Imports: stats, ash, future, future.apply, parallel, graphics,
        grDevices
Suggests: knitr, rmarkdown
Description: Indirect method for the estimation of reference intervals (RIs)
    using Real-World Data ('RWD') and methods for comparing and verifying RIs.
    Estimates RIs by applying advanced statistical methods to routine
    diagnostic test measurements, which include both pathological and
    non-pathological samples, to model the distribution of non-pathological
    samples. This distribution is then used to derive reference intervals
    and support RI verification, i.e., deciding if a specific RI is suitable
    for the local population. The package also provides functions for
    printing and plotting algorithm results. See ?refineR for a detailed
    description of features. Version 1.0 of the algorithm is described in
    'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional
    guidance is in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>. The
    verification method is described in 'Beck et al. (2025)'
    <doi:10.1515/cclm-2025-0728>.
License: GPL (>= 3)
VignetteBuilder: knitr, rmarkdown
NeedsCompilation: no
LazyData: TRUE
RoxygenNote: 7.3.2
Packaged: 2025-11-05 16:33:29 UTC; beckm25
Repository: CRAN
Date/Publication: 2025-11-06 17:20:02 UTC
Built: R 4.6.0; ; 2026-01-20 04:18:17 UTC; windows
